A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent

AR Lippert, KR Keshari, J Kurhanewicz…

Index: Lippert, Alexander R.; Keshari, Kayvan R.; Kurhanewicz, John; Chang, Christopher J. Journal of the American Chemical Society, 2011 , vol. 133, # 11 p. 3776 - 3779

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Citation Number: 48

Abstract

We report a new reaction-based approach for the detection of hydrogen peroxide (H2O2) using hyperpolarized 13C magnetic resonance imaging (13C MRI) and the H2O2-mediated oxidation of α-ketoacids to carboxylic acids. 13C-Benzoylformic acid reacts selectively with H2O2 over other reactive oxygen species to generate 13C-benzoic acid and can be hyperpolarized using dynamic nuclear polarization, providing a method for dual-frequency ...

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