Pd-catalyzed asymmetric allylic alkylation with nitromethane using a chiral diaminophosphine oxide:(S, RP)-Ph-DIAPHOX. Enantioselective synthesis of (R)-preclamol …

T Nemoto, L Jin, H Nakamura, Y Hamada

Index: Nemoto, Tetsuhiro; Jin, Long; Nakamura, Hiroshi; Hamada, Yasumasa Tetrahedron Letters, 2006 , vol. 47, # 37 p. 6577 - 6581

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Citation Number: 39

Abstract

A Pd-catalyzed asymmetric allylic alkylation with nitromethane using an aspartic acid- derived P-chirogenic diaminophosphine oxide [(S, RP)-Ph-DIAPHOX] is described. This method was successfully applied to enantioselective synthesis of (R)-preclamol and (R)- baclofen.