A New Diastereoselective Synthetic Approach to the Enantiopure Peptidomimetic Scaffold 2??Oxo??1??azabicyclo [4.4. 0] decane

C Truchot, Q Wang, NA Sasaki

Index: Truchot, Cyrille; Wang, Qian; Sasaki, N. Andre European Journal of Organic Chemistry, 2005 , # 9 p. 1765 - 1776

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Citation Number: 3

Abstract

Abstract A general method for the synthesis of unsubstituted and C-7-substituted azabicyclo [4.4. 0] decane dipeptides (23, 30a, and 30b) that can serve as dipeptide mimetics has been developed. The key step of this new method involves the coupling reaction of the oxazolidine aldehyde 5 and the sulfone 7, both of which are derived from L-glutamic acid.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)