Tetrahedron letters

Total stereospecific synthesis of all cis-5, 8, 11, 14, 17-eicosapentaenoic acid (EPA)

J Viala, J Sandri

Index: Viala, Jacques; Sandri, Jacqueline Tetrahedron Letters, 1992 , vol. 33, # 34 p. 4897 - 4900

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Citation Number: 17

Abstract

Abstract Total stereospecific synthesis of EPA has been performed by a sequence of ozonolysis, selective reduction and Wittig reactions which affords the cis-skipped olefinic system. Versatile Compound 4, readily prepared from dihydro anisole allowed us to prepare the skipped dienic synthon 2 in high yield.

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