Efforts toward expansion of the genetic alphabet: optimization of interbase hydrophobic interactions

Y Wu, AK Ogawa, M Berger, DL McMinn…

Index: Hirao, Ken-Ichi; Tsuchiya, Ryuta; Yano, Yasuhiro; Tsue, Hirohito Heterocycles, 1996 , vol. 42, # 1 p. 415 - 422

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Citation Number: 163

Abstract

... Volume: Page: ... by Klenow fragment of Escherichia coli DNA polymerase I. The unnatural base pair between pyrrolopyrizine (PP) and C3-methylisocarbostyril (MICS) is enzymatically incorporated into DNA with high efficiency (k cat /K M = 10 6 M - 1 min - 1 ...

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