Synthesis of a novel heterospirocyclic 3-(N-methyl-N-phenylamino)-2H-azirine and its use as an amino acid equivalent in the preparation of a model tripeptide

JM Villalgordo, H Heimgartner

Index: Villalgordo, Jose M.; Heimgartner, Heinz Tetrahedron, 1993 , vol. 49, # 33 p. 7215 - 7222

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Citation Number: 14

Abstract

The synthesis of a novel heterospirocyclic 3-amino-2H-azirine based on the reaction between amide enolates and diphenylphosphorochloridate is described. This compound has been shown to be a useful amino acid equivalent and the synthesis of a model tripeptide was achieved in good overall yields.