Methoxymethylation of tartrate as a strategy for the synthesis of chiral building blocks

H Dulphy, JL Gras, T Lejon

Index: Dulphy, Herve; Gras, Jean-Louis; Lejon, Tore Tetrahedron, 1996 , vol. 52, # 25 p. 8517 - 8524

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Citation Number: 23

Abstract

Controlled methoxymethylation of tartrate affords mono-and diMOMtartrates. We took advantage of the particular reactivity of methoxymethylethers and of the conformations of the starting C4 unit, to efficiently synthezise various cyclic methyleneketals (dioxane and dioxolane) or cyclic ethers (oxolane and oxetane).