Tetrahedron

Synthesis of a diterpene taxoid skeleton, bicyclo [9.3. 1] pentadecatriene

S Shibuya, M Isobe

Index: Shibuya, Satoshi; Isobe, Minoru Tetrahedron, 1998 , vol. 54, # 24 p. 6677 - 6698

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Citation Number: 32

Abstract

The synthesis of bicyclo [9.3. 1] pentadecatriene skeleton was investigated by employing cyclization reactions using two key precursors bearing acetylene cobalt complex. Cyclization for the synthesis of strained twelve-membered ring was achieved via Nicholas type reaction in reasonable yield. Reductive decomplexation of the dicobalt hexacarbonyl moiety of the cyclization product was achieved with n-Bu3SnH in the presence of a catalytic amount of ...