Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction
…, Y Goto, F Obara, M Tsuchiya, J Matsui, K Hirota…
Index: Tobe, Masanori; Isobe, Yoshiaki; Goto, Yuso; Obara, Fumihiro; Tsuchiya, Masami; Matsui, Junko; Hirota, Kosaku; Hayashi, Hideya Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 8 p. 2037 - 2047
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Citation Number: 27
Abstract
In order to find novel nonsteroidal compounds possessing an inhibitory activity against delayed-type hypersensitivity (DTH) reactions, we conducted random screening using a picryl chloride (PC)-induced contact hypersensitivity reaction (CHR) in mice, and found compound 1 as a lead compound. Then we synthesized and evaluated an extensive series of 5-carboxamidouracil derivatives focused on both the uracil and the antioxidative ...
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[Isobe, Yoshiaki; Tobe, Masanori; Inoue, Yoshifumi; Isobe, Masakazu; Tsuchiya, Masami; Hayashi, Hideya Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4933 - 4940]