Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization

…, SK Palaninathan, JC Sacchettini…

Index: Green, Nora S.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W. Journal of the American Chemical Society, 2003 , vol. 125, # 44 p. 13404 - 13414

Full Text: HTML

Citation Number: 82

Abstract

The misfolding of transthyretin (TTR), including rate-limiting tetramer dissociation and partial monomer denaturation, is sufficient for TTR misassembly into amyloid and other abnormal quaternary structures associated with senile systemic amyloidosis, familial amyloid polyneuropathy, and familial amyloid cardiomyopathy. Monovalent small molecules that bind to one or both of the unoccupied thyroid hormone binding sites at the TTR quaternary ...

Related Articles:

Triaryl-Like MONO-, BIS-, and TRISKITPHOS Phosphines: Synthesis, Solution NMR Studies, and a Comparison in Gold-Catalyzed Carbon–Heteroatom Bond Forming …

[Snelders, Dennis J. M.; Kreiter, Robert; Firet, Judith J.; Van Koten, Gerard; Gebbink, Robertus J. M. Klein Advanced Synthesis and Catalysis, 2008 , vol. 350, # 2 p. 262 - 266]

Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based β-strand mimics

[Faucher, Anne-Marie; White, Peter W.; Brochu, Christian; Grand-Maitre, Chantal; Rancourt, Jean; Fazal, Gulrez Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 18 - 21]

The orientation of p-methoxydiphenyl in the Friedel and Crafts reaction

[Fieser; Bradsher Journal of the American Chemical Society, 1936 , vol. 58, p. 1738,1740]

The orientation of p-methoxydiphenyl in the Friedel and Crafts reaction

[Fieser; Bradsher Journal of the American Chemical Society, 1936 , vol. 58, p. 1738,1740]

Mechanisms of the photochemical rearrangement of diphenyl ethers

[Haga, Naoki; Takayanagi, Hiroaki Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 735 - 745]

More Articles...