Candida tenuis Xylose Reductase Catalyzed Reduction of Aryl Ketones for Enantioselective Synthesis of Active Oxetine Derivatives

M Vogl, R Kratzer, B Nidetzky, L Brecker

Index: Vogl, Michael; Brecker, Lothar; Kratzer, Regina; Nidetzky, Bernd Chirality, 2012 , vol. 24, # 10 p. 847 - 853,7

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Citation Number: 3

Abstract

ABSTRACT Candida tenuis xylose reductase shows high catalytic efficiencies in carbonyl reduction of acetophenone and 1-phenyl-1-propanone derivatives. The quite low substrate solubility in aqueous buffer systems is circumvented by addition of methanol or by two- phase solvent systems. In the latter, methanol improves the substrate phase transfer as solvent mediator and leads to reasonable space/time yields. Resulting enantiomerically ...