Synthesis and quantitative structure-activity relationships of anticonvulsant 2, 3, 6-triaminopyridines

JK Seydel, KJ Schaper, EA Coats…

Index: Seydel; Schaper; Coats; Cordes Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3016 - 3022

Full Text: HTML

Citation Number: 29

Abstract

The synthesis of 2, 3, 6-triaminopyridine derivatives, representing a unique chemical structure for anticonvulsants, is described. The synthetic program was performed (a) to identify more potent analogs,(b) to determine structural properties controlling potency as well as neurotoxicity, and (c) to reduce the requirements for animal testing. As a result, besides other structural properties, the overall molecular lipophilicity (log k', octanol- ...

Related Articles:

2, 3??Dihydrospiro [1H??4??and 5??azabenzimidazole??2, 1′??cyclohexane](= Spiro [cyclohexane??1, 2′(3′ H)??1′ H??imidazo [4, 5??b] pyridine] and Spiro [cyclohexane?? …

[Schwoch; Kramer; Neidlein; Suschitzky Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190]

2, 3??Dihydrospiro [1H??4??and 5??azabenzimidazole??2, 1′??cyclohexane](= Spiro [cyclohexane??1, 2′(3′ H)??1′ H??imidazo [4, 5??b] pyridine] and Spiro [cyclohexane?? …

[Schwoch; Kramer; Neidlein; Suschitzky Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190]

2, 3??Dihydrospiro [1H??4??and 5??azabenzimidazole??2, 1′??cyclohexane](= Spiro [cyclohexane??1, 2′(3′ H)??1′ H??imidazo [4, 5??b] pyridine] and Spiro [cyclohexane?? …

[Schwoch; Kramer; Neidlein; Suschitzky Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190]

More Articles...