2, 3??Dihydrospiro [1H??4??and 5??azabenzimidazole??2, 1′??cyclohexane](= Spiro [cyclohexane??1, 2′(3′ H)??1′ H??imidazo [4, 5??b] pyridine] and Spiro [cyclohexane?? …

…, W Kramer, R Neidlein, H Suschitzky

Index: Schwoch; Kramer; Neidlein; Suschitzky Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190

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Citation Number: 13

Abstract

Abstract The readily available title compounds 4a and 24 react with N-, O-, S-, and C- nucleophiles in presence of MnO 2 to give the corresponding mono-or disubstituted 2H- azabenzimidazoles (= azaisobenzimidazoles), eg, 11–18 and 26a–h, respectively, or 2, 3- dihydro-1H-azabenzimidazoles (= dihydro-azabenzimidazoles) such as 9 and 10 and 27 and 28, respectively, by a 1, 4-or 1, 6-Michael addition (Schemes 2 and 4). The bromo- ...