Synthesis and biological evaluation of 3, 4, 6-triaryl-2-pyranones as a potential new class of anti-breast cancer agents

…, R Konwar, G Kharkwal, V Chandra, A Dwivedi…

Index: Shankar, Ravi; Chakravarti, Bandana; Singh, Uma Sharan; Ansari, Mohd. Imran; Deshpande, Shreekant; Dwivedi, Shailendra Kumar Dhar; Bid, Hemant Kumar; Konwar, Rituraj; Kharkwal, Geetika; Chandra, Vishal; Dwivedi, Anila; Hajela Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 11 p. 3847 - 3856

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Citation Number: 25

Abstract

A series of 3, 4, 6-triaryl-2-pyranones, new class of anti-breast cancer agents, have been synthesized as a structural variants of cyclic triphenylethylenes by replacing the fused benzene ring with pendant phenyl ring to mimic the phenolic A ring of estradiol. Nine of these newly synthesized pyranones exhibited significant anti-proliferative activity in both ER+ ve and ER− ve breast cancer cell lines. Four active non-cytotoxic compounds 5c, 5d, ...

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