Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors

CH Yao, JS Song, CT Chen, TK Yeh, TC Hsieh…

Index: Yao, Chun-Hsu; Song, Jen-Shin; Chen, Chiung-Tong; Yeh, Teng-Kuang; Hsieh, Tsung-Chih; Wu, Szu-Huei; Huang, Chung-Yu; Huang, Yu-Lin; Wang, Min-Hsien; Liu, Yu-Wei; Tsai, Chi-Hui; Kumar, Chidambaram Ramesh; Lee, Jinq-Chyi European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 32 - 38,7

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Citation Number: 10

Abstract

Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors are the current focus on the indication for the management of hyperglycemia in diabetes. Here, a novel series of C- linked indolylxyloside-based inhibitors of SGLT2 has been discovered. Structure–activity relationship studies revealed that substituents at the 7-position of the indole moiety and a p- cyclopropylphenyl group in the distal position were necessary for optimum inhibitory ...