Phytochemistry

Kinetic analysis of the inhibition of phenylalanine ammonia-lyase by 2-aminoindan-2-phosphonic acid and other phenylalanine analogues

C Appert, J Zoń, N Amrhein

Index: Appert, Christoph; Zon, Jerzy; Amrhein, Nikolaus Phytochemistry, 2003 , vol. 62, # 3 p. 415 - 422

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Citation Number: 58

Abstract

The conformationally restricted phenylalanine analogue 2-aminoindan-2-phosphonic acid (AIP) inhibits phenylalanine ammonia-lyase (PAL) competitively in a time-dependent manner. This phenomenon was investigated in more detail with the heterologously expressed, highly purified homotetrameric PAL-1 isozyme from parsley. The kinetic analysis revealed that the enzyme-inhibitor complex is formed in a single “slow” step with an ...

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