3-Aminopyridazine derivatives with atypical antidepressant, serotonergic and dopaminergic activities

CG Wermuth, G Schlewer, JJ Bourguignon…

Index: Wermuth; Schlewer; Bourguignon; Maghioros; Bouchet; Moire; Kan; Worms; Biziere Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 528 - 537

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Citation Number: 93

Abstract

Minaprine [3-[(~-morpholinoethyl) amino]-4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effects and to ...