Nitriles in heterocyclic synthesis: the preparation of novel indeno [1, 2-d] pyridazines, fused pyrazolo [5, 1-c][1, 2, 4] triazines, and fluorenones

AZA Hassanien, ZE Kandeel

Index: Hassanien, Abu Zeid A.; Kandeel, Zaghloul E. Journal of Chemical Research, Miniprint, 2003 , # 11 p. 1161 - 1174

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Abstract

Treatment of the novel compound 2-cyano-1-oxo-1H-indene-3-acetonitrile (3) with various reagents affords a variety of heterocyclic compounds in which the indenone system is incorporated into polycyclic compounds of potential pharmacological interest. ... Aroyl acetonitriles (ω-cyanoacetophenone and its derivatives) are versatile reagents and find many ... We have carried out intensive studies with activated nitriles as potential intermediates for the ... * To whom correspondence ...