Synthesis and elucidation of deuterated vanillylamine hydrochloride and capsaicin

SW Kim, JH Park, SJ Jung, TB Choi…

Index: Kim, Sang Wook; Park, Jeong Hoon; Jung, Soon Jae; Choi, Tae Bum; Hur, Min Goo; Yang, Seung Dae; Yu, Kook Hyun Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 13 p. 563 - 565

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Abstract

Abstract Capsaicin is the major pungent component of hot peppers, which belong to the plant genus Capsicum. Although the biosynthesis of capsaicin is known to involve the condensation of vanillylamine and 8-methylnonenoic acid by capsaicin synthase, the mechanism of biosynthesis is still not fully understood. In this study, deuterium labelled versions of capsaicin and the precursor vanillylamine were synthesized in order to ...