One-step preparation of 1-substituted tetrahydroisoquinolines via the Pictet–Spengler reaction using zeolite catalysts
A Hegedüs, Z Hell
Index: Hegedues, Adrienn; Hell, Zoltan Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8553 - 8555
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Citation Number: 44
Abstract
A new, environmentally friendly variation of the Pictet–Spengler reaction has been elaborated using a small pore size zeolite. The easily separable and recyclable catalyst provided high conversions and a shorter reaction time than the classical acetic acid or trifluoroacetic acid.
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