Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

…, W Chen, D Duckett, S Schürer, P LoGrasso…

Index: Yin, Yan; Lin, Li; Ruiz, Claudia; Cameron, Michael D.; Pocas, Jennifer; Grant, Wayne; Schroeter, Thomas; Chen, Weimin; Duckett, Derek; Schuerer, Stephan; LoGrasso, Philip; Feng, Yangbo Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6686 - 6690

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Citation Number: 26

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified. ... ROCK inhibitors have been developed from 2-chromanyl- and 2-carboxamido-benzothiazoles. ...