Cyclic PNA hexamer-based compound: modelling, synthesis and inhibition of the HIV-1 RNA dimerization process

…, B Ehresmann, R Terreux, D Cabrol-Bass, R Condom

Index: Schwergold, Caroline; Depecker, Geoffrey; Giorgio, Christophe Di; Patino, Nadia; Jossinet, Fabrice; Ehresmann, Bernard; Terreux, Raphael; Cabrol-Bass, Daniel; Condom, Roger Tetrahedron, 2002 , vol. 58, # 28 p. 5675 - 5687

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Citation Number: 46

Abstract

A cyclic molecule constituted by (i) a hexameric PNA moiety complementary to six among the nine residues of the dimerization initiation site loop of HIV-1 and (ii) a spacer tethering the N-to the C-extremities of the PNA, has been elaborated to inhibit the dimerization process of HIV-1 genome. This compound has been synthesized following a liquid-phase procedure (fully protected backbone approach). Preliminary agarose gel electrophoresis ...