1, 1, 2-triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties

…, E Von Angerer, H Schoenenberger…

Index: Schneider, Martin R.; Angerer, Erwin von; Schoenenberger, Helmut; Michel, Ralf Th.; Fortmeyer, H. P. Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1070 - 1077

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Citation Number: 49

Abstract

1, 1, 2-Triphenylbut-l-enes, which are substituted with acetoxy groups on one, two, or three aromatic rings in the para and/or meta positions, were synthesized. The identity of the occurring E and 2 isomers were established by lH NMR spectroscopy. A study on structure- activity relationships was carried out with regard to estradiol receptor affinity and to inhibiting effects on the growth of a postmenopausal human mammary carcinoma implanted in nude ...

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