Tetrahedron: Asymmetry

Synthesis of (R)-and (S)-isopropylidene glycerol

M Pallavicini, E Valoti, L Villa, O Piccolo

Index: Pallavicini; Valoti; Villa; Piccolo Tetrahedron Asymmetry, 1994 , vol. 5, # 1 p. 5 - 8

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Citation Number: 35

Abstract

Abstract The preparation of (R)-and (S)-isopropylidene glycerol 1 of high enantiomeric excess (> 98%) was accomplished through salt formation between their hydrogen phthalates with (S)-and (R)-1-methylbenzylamine [MBA] respectively, selective crystallization of these salts and subsequent regeneration of optically active compounds 1 by saponification. The progress of resolution was followed by HPLC analysis on Chiralcel ...