A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin

…, C Gerding??Reimers, TT Ngoc Tran…

Index: Voigt, Tobias; Gerding-Reimers, Claas; Tran, Tuyen Thi Ngoc; Bergmann, Sabrina; Lachance, Hugo; Schoelermann, Beate; Brockmeyer, Andreas; Janning, Petra; Ziegler, Slava; Waldmann, Herbert Angewandte Chemie - International Edition, 2013 , vol. 52, # 1 p. 410 - 414 Angew. Chem., 2013 , vol. 125, # 1 p. 428 - 432

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Citation Number: 34

Abstract

In biology-oriented synthesis (BIOS) biological relevance and prevalidation are employed as key criteria for the design and synthesis of focused compound collections for chemical biology and medicinal chemistry research.[1] The scaffolds of natural products are privileged, biologically relevant molecular frameworks and natural products, and analogues thereof have served as efficient probes in chemical research, for example, in the study of ...