A new class of analog of the bifunctional radiosensitizer. alpha.-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines

…, MA Stier, LM Werbel, CM Arundel-Suto…

Index: Suto; Stier; Werbel; Arundel-Suto; Leopold; Elliott; Sebolt-Leopold Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2484 - 2488

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Citation Number: 11

Abstract

Radiotherapy continues to play a major role in the treatment of many forms of human cancer. 2 Although successful in some cases, ca. 30% of patients treated with radiation eventually succumb to lack of control of the primary disease. The failure of radiotherapy has been attributed to many factors, one of which is the presence of radioresistant hypoxic cells found in many solid tum0rs.~ 3'Studies have demonstrated that tumors contain various ...

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