Design, Synthesis, and Characterization of SO2-Containing Azabicyclo [3. n. 1] alkanes: Promising Building Blocks for Drug Discovery

…, SS Shishkina, A Tolmachev, PK Mykhailiuk

Index: Denisenko, Aleksandr V.; Mityuk, Andrey P.; Grygorenko, Oleksandr O.; Volochnyuk, Dmytro M.; Shishkin, Oleg V.; Tolmachev, Andrey A.; Mykhailiuk, Pavel K. Organic Letters, 2010 , vol. 12, # 19 p. 4372 - 4375

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Citation Number: 8

Abstract

A set of novel SO2-containing azabicyclo [3. n. 1] alkanes has been synthesized by the double-Mannich annulation of of the corresponding monocyclic S-ketones. These compounds have been rationally designed as 3D-shaped, conformationally restricted SO2-