Design, synthesis and biological evaluation of glucose-containing scutellarein derivatives as neuroprotective agents based on metabolic mechanism of scutellarin in …

…, MZ Shen, ZJ Wang, YP Tang, ZH Shi, YF Fu…

Index: Li, Nian-Guang; Shen, Min-Zhe; Wang, Zhen-Jiang; Tang, Yu-Ping; Shi, Zhi-Hao; Fu, Yi-Fan; Shi, Qian-Ping; Tang, Hao; Duan, Jian-Ao Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 102 - 106

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Citation Number: 21

Abstract

Based on metabolic mechanism of scutellarin in vivo that scutellarin could be hydrolyzed into scutellarein by β-glucuronide enzyme, some glucose-containing scutellarein derivatives were designed and synthesized through the introduction of glucose moiety at C-7 position of scutellarein via a glucosidic bond. Biological activity evaluation showed that these glucose- containing scutellarein derivatives exhibited potent DPPH radical scavenging activities. ...