Tetrahedron

Synthesis of migrastatin and its macrolide core

S Reymond, J Cossy

Index: Reymond, Sebastien; Cossy, Janine Tetrahedron, 2007 , vol. 63, # 26 p. 5918 - 5929

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Citation Number: 32

Abstract

Migrastatin and its macrolactone subunit are potent antimetastatic agents. Both were synthesized by using a ring-closing metathesis (RCM) to establish the macrolactone core, and the control of the (Z)-trisubstituted double bond at C11–C12 was achieved by using a Still–Gennari olefination.