Efficient and versatile synthesis of a-ring precursors of 1α, 25-dihydroxy-vitamin D 3 and analogues. Application to the synthesis of Lythgoe-Roche phosphine oxide

…, M Torneiro, C Vitale, S Fernández, J Pérez-Sestelo…

Index: Mourino, Antonio; Torneiro, Mercedes; Vitale, Cristian; Fernandez, Sara; Perez-Sestelo, Jose; Anne, Sofia; Gregorio, Carlos Tetrahedron Letters, 1997 , vol. 38, # 26 p. 4713 - 4716

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Citation Number: 39

Abstract

An efficient, versatile synthesis of Lythgoe-Phosphine Oxide has been developed starting from l-carvone. The key steps are rupture of protected epoxide 7 to give dicarbonyl compound 8, preparation of vinylic triflate 2, and palladium-catalysed cyclization- carbonylation of vinylic triflate 2.