5-Diacetoxymethyl-cyclo Sal-d4TMP—A prototype of enzymatically activated cyclo Sal-pronucleotides

N Gisch, J Balzarini, C Meier

Index: Gisch; Balzarini; Meier Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 6-7 p. 861 - 864

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Citation Number: 5

Abstract

A new class of “lock-in”-modified cyclo Sal-pronucleotides has been synthesized. On the example of 5-diacetoxymethyl-cyclo Sal-d4T-monophosphate (5-di-AM-cyclo Sal-d4TMP), the concept of enzymatically activated cyclo Sal-pronucleotides is elucidated. Synthesis, hydrolysis studies, and antiviral activities against HIV are presented.