Synthesis and PET evaluation of (R)??[S??methyl??11C] thionisoxetine, a candidate radioligand for imaging brain norepinephrine transporters

…, A Varrone, B Gulyas, L Farde, C Halldin

Index: Schou, Magnus; Pike, Victor W.; Varrone, Andrea; Gulyas, Balazs; Farde, Lars; Halldin, Christer Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 11 p. 1007 - 1019

Full Text: HTML

Citation Number: 16

Abstract

Abstract Introduction:(R)-3-(2-(methylthio) phenoxy)-N-methyl-3-phenylpropan-1-amine [(R)– thionisoxetine; 1] is a potent inhibitor of the norepinephrine transporter (NET). We aimed to label 1 with carbon-11 (t 1/2= 20.4 min) for evaluation as a radioligand for imaging NET in living brain with positron emission tomography (PET). Methods: Methyl 3-(2-((R)-3- (methylamino)-1-phenylpropoxy) phenylthio)-propanoate (MPPP) and 1 were each ...

Related Articles:

Synthetic routes to polyheteroacenes: Characterization of a heterocyclic ladder polymer containing phenoxathiinium-type building blocks

[Oyaizu, Kenichi; Mikami, Takefumi; Mitsuhashi, Fumio; Tsuchida, Eishun Macromolecules, 2002 , vol. 35, # 1 p. 67 - 78]

Electrophilic substitutions with the electrogenerated sulfenium cation R 1-S+

[Tetrahedron Letters, , vol. 39, # 26 p. 4657 - 4658]

Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators

[Journal of Medicinal Chemistry, , vol. 41, # 24 p. 4800 - 4818]

Electrophilic substitutions with the electrogenerated sulfenium cation R 1-S+

[Tetrahedron Letters, , vol. 39, # 26 p. 4657 - 4658]

Alkylmercaptophenols by sulfenylation of phenols

[Journal of Organic Chemistry, , vol. 28, p. 2807 - 2809]

More Articles...