A concise synthesis of HIV integrase inhibitors bearing the dipyridone acid motif

…, CG Barber, JY Chiva, RL Eastwood, DR Fenwick…

Index: Platts, Michelle Y.; Barber, Christopher G.; Chiva, Jean-Yves; Eastwood, Rachel L.; Fenwick, David R.; Paradowski, Kerry A.; Blakemore, David C. Tetrahedron Letters, 2011 , vol. 52, # 4 p. 512 - 514

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Citation Number: 5

Abstract

An efficient route to dipyridone acid HIV integrase inhibitors is developed. The key steps include a one-pot three-step formation of the core template (containing one point of structural diversity) followed by a regioselective benzylation and in situ deprotection to afford the title compounds.