Journal of heterocyclic chemistry

Preparation of 1, 2??disubstituted??3??hydroxy??4 (1H)??quinolinones and the influence of substitution on the course of cyclization

P Hradil, J Hlaváč, K Lemr

Index: Hradil, Pavel; Hlavac, Jan; Lemr, Karel Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 141 - 144

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Citation Number: 45

Abstract

Abstract Synthesis of 1, 2-disubstituted-3-hydroxy-4 (1H)-quinolinones by the cyclization of N-substituted phenacyl or acetonyl anthranilates is described. Two methods were employed for cyclization of anthranilates. Heating in polyphosphoric acid has a wide scope of applicability. The thermal cyclization in boiling N-methylpyrrolidone is limited by steric effect.