Arylpiperazines displaying preferential potency against chloroquine-resistant strains of the malaria parasite Plasmodium falciparum

CA Molyneaux, M Krugliak, H Ginsburg…

Index: Molyneaux, Carrie-Anne; Krugliak, Miriam; Ginsburg, Hagai; Chibale, Kelly Biochemical Pharmacology, 2005 , vol. 71, # 1-2 p. 61 - 68

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Citation Number: 21

Abstract

Arylpiperazines in which the terminal secondary amino group is unsubstituted were found to display a mefloquine-type antimalarial behavior in being significantly more potent against the chloroquine-resistant (W2 and FCR3) strains of Plasmodium falciparum than against the chloroquine-sensitive (D10 and NF54) strains. Substitution of the aforementioned amino group led to a dramatic drop in activity across all strains as well as abolition of the ...

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