Synthesis and screening of novel vitamin E derivatives for anticancer functions

W Chen, SK Park, W Yu, A Xiong, BG Sanders…

Index: Chen, Wenbin; Park, Sook Kyung; Yu, Weiping; Xiong, Ailian; Sanders, Bob G.; Kline, Kimberly European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 72 - 83

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Citation Number: 6

Abstract

α-TEA, RRR-α-tocopherol ether linked acetic acid, exhibits potent anticancer actions in vitro and in vivo; whereas, the parent molecule has no anticancer activity. In this study, we incorporated fluorine at the chroman head and/or ether linkage between the chroman head and phytyl tail of α-TEA as well as RRR-α-tocopherol to synthesize 6 vitamin E derivatives, and evaluated the anticancer actions in vitro for ability to induce cell death by apoptosis of ...