Organic letters

A new synthesis of lysergic acid

JB Hendrickson, J Wang

Index: Hendrickson, James B.; Wang, Jian Organic Letters, 2004 , vol. 6, # 1 p. 3 - 5

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Citation Number: 48

Abstract

(±)-Lysergic acid (1) has been synthesized via an economical 8-step route from 4- bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.