Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel–Crafts reaction catalyzed by anhydrous stannic chloride

PH Wu, QQ Meng, HC Zhou

Index: Wu, Pu Hua; Meng, Qing Qing; Zhou, Hu Chen Chinese Chemical Letters, 2011 , vol. 22, # 12 p. 1411 - 1414

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Citation Number: 2

Abstract

A novel pyrrolo-benzoxaborole, 6-(pyrrol-1-yl)-1, 3-dihydro-1-hydroxy-2, 1-benzoxaborole, was synthesized with 27% overall yield over six steps from 2-bromo-1-methyl-4- nitrobenzene as starting material. Its derivatization was achieved via Friedel–Crafts reaction catalyzed by anhydrous stannic chloride with various acyl chlorides giving 3-acyl-1- phenylpyrroles as the main products.