Tetrahedron letters

Chemoenzymatic synthesis of duloxetine and its enantiomer: lipase-catalyzed resolution of 3-hydroxy-3-(2-thienyl) propanenitrile

A Kamal, GBR Khanna, R Ramu, T Krishnaji

Index: Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787

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Citation Number: 75

Abstract

Antidepressants (serotonin reuptake inhibitors, norepinephrine reuptake inhibitors) with 3-aryloxy-3-aryl propylamine sub-structures such as fluoxetine, 1., , , , , and tomoxetine, 2., , , and nisoxetine and duloxetine 3., , , and are among the most important pharmaceuticals for the treatment of psychiatric and metabolic disorders. Fluoxetine 4., and is a selective inhibitor of serotonin in serotonergic neurons, tomoxetine 5 and nisoxetine 6 are selective inhibitors ...

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