A simple method for chemoselective phenol alkylation

P Liu, L Huang, MM Faul

Index: Liu, Pingli; Huang, Liang; Faul, Margaret M. Tetrahedron Letters, 2007 , vol. 48, # 41 p. 7380 - 7382

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Citation Number: 8

Abstract

Phenolic ethers and carboxylic acids are found in a variety of active pharmaceutical ingredients in the pharmaceutical industry, for instance the potent fibrinogen receptor antagonist MK-383 (1), 1 and the PPAR α/γ agonist (2) 2 (Fig. 1). In addition, phenol ethers are important intermediates in medicinal chemistry. 3 Synthesis of these compounds typically suffers from the need to use protecting groups to obtain improved chemoselectivity of ether formation relative to ...