Synthesis of 9-O-glycosyl-berberine derivatives and bioavailability evaluation

Z Chen, X Ye, J Yi, X Chen, X Li

Index: Chen, Zhu; Ye, Xiaoli; Yi, Jun; Chen, Xin; Li, Xuegang Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1641 - 1646

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Citation Number: 4

Abstract

Abstract To increase the bioavailability of berberine, three new 9-O-glycosyl-berberine derivatives, 9-O-glucosyl-(4a), 9-O-arabinosyl-(4b), and 9-O-erythrol-(4c) were obtained and confirmed by UV, 1 HNMR, 13 CNMR, and MS. The pharmacokinetic profiles of these synthetic compounds have been evaluated compared with berberine (1) and 9-O-alkyl- berberine (5) derivatives, which showed that maximum concentration (C max) and area ...