Tetrahedron letters

[Ru (DMSO) 4] Cl 2 catalyzes the α-alkylation of ketones by alcohols

R Martínez, GJ Brand, DJ Ramón, M Yus

Index: Martinez, Ricardo; Brand, Gabriel J.; Ramon, Diego J.; Yus, Miguel Tetrahedron Letters, 2005 , vol. 46, # 21 p. 3683 - 3686

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Citation Number: 112

Abstract

The electrophilic α-alkylation of ketones with alcohols was accomplished by a [Ru (DMSO) 4] Cl2 catalyzed process, water being the only wasted material. The reaction can be successfully governed to produce either the expected ketones or their related alcohols only by changing the reaction conditions. When 2-aminobenzyl alcohol was used, a cyclization process took place to yield 2, 3-disubstituted quinolines.

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