Synthesis of polysubstituted pyridines under combined microwave and ultrasound irradiation: K 2 CO 3-promoted tandem addition/cyclization/hydrogen shift process

H Feng, Y Li, EV Van der Eycken, Y Peng, G Song

Index: Feng, Huangdi; Li, Yuan; Van Der Eycken, Erik V.; Peng, Yanqing; Song, Gonghua Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1160 - 1162

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Citation Number: 22

Abstract

A convenient and efficient K2CO3-promoted tandem reaction of chalcone, malononitrile, and methanol for the synthesis of highly functionalized pyridines has been developed. This multi- component reaction employing the weak nucleophilic agent methanol proceeded smoothly under combined microwave and ultrasound irradiation (CMUI). The reaction mechanism was proposed to consist of a Michael addition, a methoxylation of CN bond, a cyclization ...