The Journal of Organic Chemistry

Synthesis of Purine and Pyrimidine Isodideoxynucleosides from (S)-Glycydol Using Iodoetherification as Key Step. Synthesis of (S, S)-iso-ddA1

Y Díaz, F Bravo, S Castillón

Index: Diaz, Yolanda; Bravo, Fernando; Castillon, Sergio Journal of Organic Chemistry, 1999 , vol. 64, # 17 p. 6508 - 6511

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Citation Number: 39

Abstract

Analogues of natural nucleosides have proved to be efficient antiviral agents. The chemistry of nucleosides is a field that is being actively investigated in the search for new antiviral drugs with improved biological properties and minimun toxic effects. Consequently, many different families of nucleoside analogues have been synthesized. Of these, 2′, 3′- dideoxynucleosides have been extensively studied, 2 and some of them have been ...