Novel Fluoroquinolone Antibacterial Agents Containing Oxime-Substituted (Aminomethyl) pyrrolidines: Synthesis and Antibacterial Activity of 7-(4-(Aminomethyl)-3-( …
…, JH Chang, SH Kim, H Choi, DH Nam…
Index: Hong, Chang Yong; Kim, Young Kwan; Chang, Jay Hyok; Kim, Se Ho; Choi, Hoon; Nam, Do Hyun; Kim, Yong Zu; Kwak, Jin Hwan Journal of Medicinal Chemistry, 1997 , vol. 40, # 22 p. 3584 - 3593
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Citation Number: 130
Abstract
New pyrrolidine derivatives, which bear an alkyloxime substituent in the 4-position and an aminomethyl substituent in the 3-position of the pyrrolidine ring, have been synthesized and coupled with various quinolinecarboxylic acids to produce a series of new fluoroquinolone antibacterials. These fluoroquinolones were found to possess potent antimicrobial activity against both Gram-negative and Gram-positive organisms, including methicillin resistant ...
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