Synthesis and biological activity of novel 1β-methylcarbapenems with oxyiminopyrrolidinylamide moiety

…, YK Kang, KH Yoo, KJ Shin, DC Kim, JY Kong…

Index: Lee, Ji Hoon; Lee, Kyung Seok; Kang, Yong Koo; Yoo, Kyung Ho; Shin, Kye Jung; Kim, Dong Chan; Kong, Jae Yang; Lee, Yeonhee; Lee, Sook Ja; Kim, Dong Jin Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4399 - 4403

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Citation Number: 11

Abstract

The synthesis and antibacterial activity of novel 1β-methylcarbapenems 1a–f bearing oxyiminopyrrolidinylamide moiety at C-5 position of pyrrolidine are described. Most compounds exhibited comparable antibacterial activity to meropenem against a wide range of Gram-positive and Gram-negative organisms including Pseudomonas aeruginosa isolates. Of these carbapenems, 1a showed potent and broad spectrum of antibacterial ...