Redox-active dinitrodiphenylthioethers against Leishmania: Synthesis, structure–activity relationships and mechanism of action studies

DA Delfín, RE Morgan, X Zhu, KA Werbovetz

Index: Delfin, Dawn A.; Morgan, Rachel E.; Zhu, Xiaohua; Werbovetz, Karl A. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 2 p. 820 - 829

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Citation Number: 33

Abstract

BTB 06237 (2-[(2, 4-dichloro-5-methylphenyl) sulfanyl]-1, 3-dinitro-5-(trifluoromethyl) benzene), a compound previously identified through QSAR pharmacophore development and a virtual screen of the Maybridge database, possesses potent and selective activity against Leishmania parasites. In the present study, several analogs of BTB 06237 were synthesized and analyzed for activity against Leishmania axenic amastigotes, their ability ...