An indicator displacement system for fluorescent detection of phosphate oxyanions under physiological conditions

RG Hanshaw, SM Hilkert, H Jiang, BD Smith

Index: Hanshaw, Roger G.; Hilkert, Sarah M.; Jiang, Hua; Smith, Bradley D. Tetrahedron Letters, 2004 , vol. 45, # 47 p. 8721 - 8724

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Citation Number: 120

Abstract

A fluorogenic chemosensing system is described and shown to selectively detect pyrophosphate under physiological conditions. In the best case, pyrophosphate and hydrogen phosphate are capable of displacing a fluorescent coumarin-derived indicator from a bis Zn2+-dipicolylamine coordination compound with association constants of 107 and 105M− 1, respectively.