Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

…, G Aydin, A Gumus, S Karadeniz, HI Ugras…

Index: Sokmen, Bahar Bilgin; Aydin, Gulsah; Gumus, Arzu; Karadeniz, Seref; Ugras, Halil Ibrahim; Yanardag, Refiye; Cakir, Umit Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 4 p. 870 - 875

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Abstract

A series of some 4-(aza substituted) methylene substituted dihydroxy coumarines were evaluated for their antioxidant and antielastase activities. Different in vitro methodologies such as total reducing power, 1, 1-diphenyl-2-picryl-hydrazil (DPPH·) free radical scavenging, ABTS radical scavenging activity were used as antioxidant activity. All the tested compounds exhibited potent free radical scavenging ability and antielastase ...