Synthesis and evaluation of 3-substituted 17-methylmorphinan analogs as potential anticonvulsant agents

AH Newman, K Bevan, N Bowery…

Index: Newman, Amy Hauck; Bevan, Kathryn; Bowery, Norman; Tortella, Frank C. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4135 - 4142

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Citation Number: 22

Abstract

Dextromethorphan (1,(+)-3-methoxy-17-methylmorphinan) demonstrates anticonvulsant activity in a variety of in vitro and in vivo models of convulsive action. It is well known that 1 is metabolized to its phenolic derivative dextrorphan (2) and this metabolite is also a potent anticonvulsant. A series of (+)-3-substituted-17-methylmorphinans, which are structurally similar to 1 but are either not expected to be metabolized to 2 or might do so at a reduced ...

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